Table 5.

Common pathway terms (>10%) associated with stage, grade, and diagnostic PSA.^*

		Stage			Grade			PSA
Gene Ontology Biological Process Term	N*	OR	95% CI	P	OR	95% CI	P	Beta	SE	P
Regulation of apoptosis	21	6.76	1.82-25.15	0.004	1.61	0.52-5.04	0.410	0.31	0.164	0.067
Transmembrane receptor protein tyrosine kinase signaling pathway	13	3.38	0.93-12.31	0.065	5.34	1.37-20.87	0.016	0.25	0.186	0.176
Apoptosis	12	1.87	0.51-6.85	0.347	4.36	1.13-16.83	0.033	0.14	0.193	0.477
Positive regulation of cell differentiation	12	2.27	0.63-8.19	0.209	5.73	1.44-22.78	0.013	0.57	0.179	0.002
Regulation of cellular component size	12	4.02	1.04-15.49	0.043	1.78	0.49-6.48	0.384	0.17	0.194	0.393
Aromatic compound catabolic process	12	4.91	1.22-19.78	0.025	2.90	0.76-11.03	0.118	0.19	0.198	0.347
Response to wounding	10	4.20	1.00-17.72	0.050	4.53	1.07-19.21	0.041	0.42	0.200	0.038
M phase	10	4.31	0.95-19.58	0.059	7.35	1.47-36.80	0.015	0.39	0.210	0.069
Regulation of growth	9	3.68	0.88-15.36	0.073	0.94	0.23-3.87	0.932	0.23	0.207	0.275
Protein amino acid dephosphorylation	9	10.02	1.62-61.94	0.013	5.63	1.09-29.15	0.039	0.64	0.211	0.004
Metal ion transport	9	1.21	0.27-5.49	0.802	5.27	1.04-26.78	0.045	0.27	0.228	0.242
Transcription initiation	8	5.11	0.91-28.83	0.065	1.41	0.27-7.26	0.681	0.42	0.236	0.081
Steroid biosynthetic process	8	7.42	1.37-40.31	0.020	1.72	0.38-7.75	0.483	0.37	0.222	0.102
Reproductive developmental process	7	2.56	0.48-13.72	0.271	1.42	0.27-7.61	0.680	0.22	0.250	0.381
Reproductive cellular process	7	3.89	0.76-19.87	0.103	4.26	0.83-21.74	0.081	0.80	0.213	3.84×10-4
Cell division	7	7.09	1.1-45.80	0.039	7.38	1.13-48.37	0.037	0.31	0.247	0.215

^*Adjusted for age and race. Bolded results indicate p-values < 0.05.

**N=number of tumors with over-representation of the pathway term at a p-value < 0.1.