Table 2.
Association of SNPs in the LTA and TNFA genes with Chronic Obstructive Pulmonary Disease (COPD)
| COPD cases vs. healthy control | ||||||
|---|---|---|---|---|---|---|
| Gene position | SNP ID | Seattle SNP database | COPD cases MAF % | Healthy controls MAF % | ORadj (95% CI) a | P-value* |
| LTA | ||||||
| +49(C/A) | rs2239704 | Lt_2202 | 0.42 | 0.39 | 1.05 (0.79-1.4) | 0.73 |
| +252(A/G) | rs909253 | Lt_2374 | 0.30 | 0.30 | 1.08 (0.79-1.46) | 0.63 |
| +495(T/C) | rs2229094 | Lt_2619 | 0.31 | 0.33 | 0.83 (0.62-1.11) | 0.2 |
| +720(C/A) | rs1041981 | Lt_2847 | 0.29 | 0.30 | 1.05 (0.77-1.42) | 0.78 |
| TNFA | ||||||
| -863(C/A) | rs1800630 | Lt_4539 | 0.16 | 0.22 | 0.58 (0.41-0.83) | 0.002 |
| 0.50 (0.33-0.77) | 0.001** | |||||
| -857(C/T) | rs1799724 | Lt_4545 | 0.09 | 0.09 | 1.41 (0.88-2.27) | 0.16 |
| -376(G/A) | rs1800750 | TNF_214 | 0.04 | 0.03 | 1.30 (0.64-2.66) | 0.47 |
| -308(G/A) | rs1800629 | TNF_282 | 0.15 | 0.15 | 0.97 (0.66-1.42) | 0.87 |
| -238(G/A) | rs361525 | TNF_352 | 0.06 | 0.06 | 1.25 (0.72-2.19) | 0.43 |
| +489(G/A) | rs180610 | TNF_1078 | 0.09 | 0.09 | 1.42 (0.88-2.22) | 0.15 |
Data are presented as MAF: minor allele frequency (%). ORadj: odds ratio; CI: confidence interval. *p values < 0.05. Age and gender were included in a multivariate logistic regression analyses as potential confounding factors in an additive model. **p value from a dominant genetic model.