Table 5.

Haplotype frequency of the LTA and TNFA genes SNPs in COPD patients vs. Healthy control individuals

	Haplotypes*	Total freq.	Healthy controls n = 432	COPD cases n = 199	ORadj (95%CI)ª	p-value
1	A A T C C C G G G G	0.2827	0.2806	0.2982	1.00
2	C A C C A C G G G G	0.1703	0.1815	0.1461	0.70 (0.45 - 1.08)	0.11
3	C G T A C C G A G G	0.1311	0.1328	0.1220	1.03 (0.64 - 1.66)	0.90
4	C G T A C C G G G G	0.1268	0.1280	0.1257	1.09 (0.67 - 1.78)	0.72
5	C A C C C C G G G G	0.0806	0.0723	0.0944	1.27 (0.72 - 2.23)	0.40
6	A A T C C T G G G A	0.0762	0.0749	0.0781	1.33 (0.76 - 2.35)	0.32
7	C A C C C C A G A G	0.0251	0.0205	0.0327	1.74 (0.75 - 4.00)	0.19
8	C A C C C C G G A G	0.0202	0.0196	0.0212	1.54 (0.59 - 4.02)	0.38
9	C A T C C C G G G G	0.0165	0.0177	0.0139	1.59 (0.56 - 4.48)	0.38
10	Rare	0.0703

*Haplotypes: LT+49, LT+252, LT+495, LT+720, TNF-863, TNF-857, TNF-376, TNF-308, TNF-238, TNF+489.

ª ORadj: odds ratio adjusted by age and gender; CI: confidence interval.