Table 2.

Densities and proportions of mast cell populations in different lung compartments

			Controls	CF	p-value	IPF	p-value
Small Airways (mast cell/mm2)		MCTot	357 (274-530)	89 (59-145)	0.002	357 (199-488)	0.8
		MCT	332 (204-500)	65 (42-121)	0.002	197 (62-267)	0.004
		MCTC	23 (17-73)	23 (9-74)	0.7	156 (114-249)	0.0003
		%MCTC	6 (4-26)	30 (13-54)	0.01	52 (42-69)	0.0003
Pulmonary Vessels (mast cell/mm2)		MCTot	217 (124-522)	30 (24-60)	0.002	132 (89-260)	0.03
		MCT	123 (38-338)	15 (6-34)	0.002	21 (9-42)	0.0006
		MCTC	89 (28-185)	18 (14-26	0.002	97 (77-223)	0.05
		%MCTC	46 (13-70)	59 (47-83)	0.2	84 (71-93)	0.0003
Alveolar parenchyma (mast cell/mm2)	Normal	MCTot	28 (9-85)	58 (39-151)	0.1	65 (15-120)	0.1
		MCT	26 (9-83)	52 (32-61)	0.2	54 (12-107)	0.2
		MCTC	2 (0-6)	6 (3-90)	0.02	12 (2-16)	0.01
		%MCTC	5 (0-11)	18 (5-60)	0.03	17 (11-18)	0.005
	Inflam-matory	MCTot	-	96 (59-150)	0.02*	193 (74-274)	0.0006*
		MCT	-	73 (53-115)	0.02*	88 (15-114)	0.05*
		MCTC	-	7 (5-65)	0.01*	105 (59-171)	0.001*
		%MCTC	-	14 (4-42)	0.07*	62 (43-80)	0.001*
	Fibrotic	MCTot	-	87 (77-137)	0.006*	192 (64-327)	0.001*
		MCT	-	70 (44-78)	0.07*	105 (11-181)	0.009*
		MCTC	-	20 (10-69)	0.004*	88 (19-147)	0.001*
		%MCTC	-	22 (16-51)	0.004*	49 (24-82)	0.001*

Data presented as median (range). p-value is considered significant ≤ 0.05. *Denotes comparison to normal parenchyma in control subjects.