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. Author manuscript; available in PMC: 2012 May 3.
Published in final edited form as: Nature. 2011 Sep 7;479(7371):131–134. doi: 10.1038/nature10448

Figure 3. Developmental potential of haploid ESCs.

Figure 3

(a) GFP marked haploid HAP-2 ESCs (p18) contribute to chimeric embryos at E12.5. 6 out of 9 embryos showed GFP contribution. A GFP negative embryo is shown as a control (below). (b) Representative flow analyses of DNA content of all cells (above) and GFP positive cells (below) extracted from a chimeric E12.5 embryo are shown. All 6 embryos gave similar results. (c) Live born chimeric mice were obtained from GFP marked HAP-2 ESCs. (d) Chimeric mice obtained from injection of HAP-1 ESCs into C57BL/6 blastocysts (black) show coat colour contribution from the ESCs (agouti).