Table 3. Logistic regression analysis with adjustment for confounding factors.
|
Susceptibility genotype |
Total AMD patients |
nAMD |
PCV |
RAP |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| p-value | OR | 95%CI | p-value | OR | 95%CI | p-value | OR | 95%CI | p-value | OR | 95%CI | |
|
rs800292 (CFH) | ||||||||||||
| GG (rec) |
2.36×10−8 |
2.47 |
1.79–3.41 |
7.66×10−8 |
2.90 |
1.96–4.27 |
1.42×10−5 |
2.26 |
1.55–3.27 |
0.029 |
2.09 |
1.08–4.06 |
| GG+GA (dom) |
3.33×10−4 |
2.71 |
1.57–4.67 |
6.22×10−3 |
2.68 |
1.32–5.34 |
8.46×10−3 |
2.32 |
1.23–4.39 |
|
|
|
|
rs10490924 (ARMS2) | ||||||||||||
| GT+TT (dom) |
3.85×10−6 |
2.29 |
1.61–3.26 |
2.00×10−5 |
2.59 |
1.67–4.02 |
5.88×10−3 |
1.75 |
1.17–2.62 |
0.001 |
11.60 |
2.69–50.03 |
| TT (rec) |
2.37×10−19 |
5.74 |
3.76–8.77 |
3.24×10−16 |
7.03 |
4.40–11.23 |
1.54×10−6 |
3.37 |
2.09–5.42 |
1.54×10−13 |
22.18 |
9.74–50.50 |
|
rs2301995 (ELN) | ||||||||||||
| CC (rec) |
|
|
|
2.2×10−2 |
1.58 |
1.07–2.35 |
|
|
|
|
|
|
| CC+CT (dom) |
|
|
|
|
|
|
|
|
|
|
|
|
|
rs1801133 (MTHFR) | ||||||||||||
| CC (rec) |
|
|
|
2.50×10−3 |
1.82 |
1.23–2.68 |
|
|
|
|
|
|
| CC+CT (dom) | ||||||||||||
Logistic regression analysis was performed for each genotype with adjustment for confounding factors (age, gender, hypertension, diabetes mellitus and smoking). Abbreviations: AMD represents age-related macular degeneration, nAMD represents neovascular age-related macular degeneration, PCV represents polypoidal choroidal vasculopathy, RAP represents retinal angiomatous proliferation, CI represents confidence intervals, dom represents dominant model, rec represents recessive model. p-values for comparisons between the case and control groups. p-values for genotypes were calculated using Fisher's exact test. p<0.05. Blanks indicate no siginificant difference.