Table 1.
ADAPT study sample: baseline characteristics of ADAPT
| All participants | Depressed at baseline | |||||||
|---|---|---|---|---|---|---|---|---|
| Characteristics | Total | Celecoxib | Naproxen Sodium |
Placebo | Total | Celecoxib | Naproxen Sodium |
Placebo |
| Number of participants | 2528 | 726 | 719 | 1083 | 449 | 133 | 124 | 192 |
| Age, y | ||||||||
| Median | 74.5 | 74.5 | 74.5 | 74.4 | 75.1 | 75.9 | 74.4 | 75.0 |
| First/third quartile | 72.3/77.5 | 72.1/77.5 | 72.3/77.5 | 72.4/77.5 | 72.7/78.1 | 73.4/78.7 | 72.2/78.1 | 72.6/77.9 |
| Range | 70.0- 90.6 |
70.0-90.6 | 70.0-89.0 | 70.0-90.5 | 70.1-90.6 | 70.5-90.6 | 70.1-89.0 | 70.1-85.5 |
| Sex, % | ||||||||
| F | 45.9 | 47.1 | 45.9 | 45.1 | 46.5 | 51.9 | 46.0 | 43.2 |
| M | 54.1 | 52.9 | 54.1 | 54.9 | 53.5 | 48.1 | 54.0 | 56.8 |
| Ethnicity/race,% | ||||||||
| white | 97.0 | 96.1 | 97.1 | 97.4 | 94.2 | 93.2 | 93.5 | 95.3 |
| African-American | 1.5 | 1.8 | 1.8 | 1.0 | 2.4 | 2.3 | 4.0 | 1.6 |
| Hispanic | 0.7 | 1.4 | 0.3 | 0.6 | 1.6 | 3.8 | 0.8 | 0.5 |
| Other | 0.8 | 0.6 | 0.7 | 0.9 | 1.6 | 0.0 | 1.6 | 2.6 |
| Did not answer | 0.1 | 0.1 | 0.1 | 0.1 | 0.2 | 0.8 | 0.0 | 0.0 |
| Marital status, % | ||||||||
| Married | 71.9 | 70.2 | 75.0 | 70.9 | 68.2 | 60.2 | 76.6 | 68.2 |
| Widowed | 18.2 | 19.7 | 16.1 | 18.7 | 21.6 | 28.6 | 16.9 | 19.8 |
| Divorced/separated | 7.3 | 7.3 | 6.1 | 8.0 | 7.1 | 6.8 | 4.0 | 9.4 |
| Single | 2.6 | 2.8 | 2.8 | 2.3 | 3.1 | 4.5 | 2.4 | 2.6 |
| Education, % | ||||||||
| <High school | 4.0 | 3.9 | 4.9 | 3.6 | 6.2 | 6.8 | 5.6 | 6.3 |
| High School degree | 19.9 | 20.8 | 17.5 | 20.9 | 24.3 | 24.8 | 22.6 | 25.0 |
| College, no degree | 27.5 | 27.7 | 28.4 | 26.8 | 26.9 | 29.3 | 29.0 | 24.0 |
| College degree | 19.1 | 19.1 | 17.0 | 20.6 | 17.6 | 13.5 | 15.3 | 21.9 |
| Post graduate | 29.4 | 28.5 | 32.3 | 28.2 | 24.9 | 25.6 | 27.4 | 22.9 |
| Karnofsky scoring, % | ||||||||
| 100 | 82.3 | 84.3 | 80.1 | 82.5 | 78.6 | 76.7 | 85.5 | 75.5 |
| 90 | 15.3 | 13.5 | 18.2 | 14.6 | 17.6 | 19.5 | 12.1 | 19.8 |
| 80 | 2.2 | 2.1 | 1.4 | 2.8 | 3.3 | 3.0 | 2.4 | 4.2 |
| 60-70 | 0.2 | 0.1 | 0.3 | 0.2 | 0.4 | 0.8 | 0.0 | 0.5 |
| GDS scores distribution, % | ||||||||
| GDS score 0-5 | 79.7 | 79.9 | 79.7 | 79.6 | 0.0 | 0.0 | 0.0 | 0.0 |
| GDS score 6-10 | 15.7 | 15.4 | 15.7 | 16.0 | 78.0 | 75.2 | 76.6 | 80.7 |
| GDS score 11-15 | 3.6 | 3.3 | 4.2 | 3.3 | 17.8 | 17.3 | 22.6 | 15.1 |
| GDS score >15 | 0.9 | 1.4 | 0.4 | 1.0 | 4.2 | 7.5 | 0.8 | 4.2 |
|
ADAPT measures GDS score |
||||||||
| Mean (sd) | 3.4 (3.4) | 3.4 (3.5) | 3.3 (3.4) | 3.4 (3.4) | 8.7 (3.1) | 9.1(3.6) | 8.5 (2.5) | 8.6 (3.0) |
| First/third quartile | 1.0/5.0 | 1.0/5.0 | 1.0/5.0 | 1.0/5.0 | 6.0/10.0 | 6.0/10.0 | 6.0/10.0 | 6.0/10.0 |
| Range | 0.0-24.0 | 0.0-23.0 | 0.0-24.0 | 0.0-22.0 | 6.0-23.0 | 6.0-23.0 | 6.0-18.0 | 6.0-22.0 |
| 3MS-E score | ||||||||
| Mean (sd) | 94.1(3.6) | 94.3 (3.4) | 94.1(3.6) | 94.0 (3.6) | 94.0 (3.7) | 94.0 (3.3) | 94.1 (3.4) | 93.9 (4.0) |
| First/third quartile | 92.0/96.0 | 92.0/97.0 | 92.0/96.0 | 92.0/96.0 | 92.0/96.0 | 92.0/96.0 | 92.5/96.0 | 92.0/96.0 |
| Range | 74.0- 100.0 |
80.0- 100.0 |
76.0- 100.0 |
74.0- 100.0 |
78.0- 100.0 |
84.0-100.0 | 82.0- 100.0 |
78.0- 100.0 |