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Proposed mechanisms by which resveratrol regulates SIRT1-FOXO3a leading to decreased p47phox expression and ROS production. High glucose suppresses SIRT1-FOXO3a pathway leading to increaesed p47phox gene expression and ROS production. Resveratrol treatment of HG-induced cells activates the HDACs activity and induces SIRT1 and FOXO3a expression, subsequently suppressing production of ROS and p47phox activation.
