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. Author manuscript; available in PMC: 2012 Mar 16.
Published in final edited form as: Cell. 2011 Sep 16;146(6):992–1003. doi: 10.1016/j.cell.2011.07.039

Figure 1. Deprivation-induced synaptic plasticity in AGRP and POMC neurons.

Figure 1

(A) mEPSCs from fed and food-deprived (dep) mice.

(B) fmEPSC in AGRP neurons from deprived mice in the light period or from fed mice at transition to the dark period (DP) were both significantly increased over fmEPSC from fed mice in the light period.

(C) Fluorescence micrograph of arcuate nucleus from pomc-topazFP, npy-sapphireFP double transgenic mouse. POMC neurons (green) and AGRP neurons (blue) are intermingled.

(D) In POMC neurons, fmEPSC is decreased by food-deprivation.

(E) Elevated spontaneous firing rate in AGRP neurons from deprived mice (n = 11) is reduced to the level of fed mice (n = 12) by CNQX.

***P < 0.001. Data are represented as mean ± s.e.m. See also Figure S1.