. Author manuscript; available in PMC: 2012 Dec 5.

Published in final edited form as: Eur J Pharmacol. 2011 Sep 24;671(1-3):39–44. doi: 10.1016/j.ejphar.2011.09.162

Table 1.

Affinity of Drugs at DAT, SERT, and NET in Rat Brain as Determined in Uptake Assays.

Drugs	DAT uptake, Ki, nM, [³H]DA^a	SERT uptake, Ki, nM, [³H]5-HT^a	NET uptake, Ki, nM [³H]NE^a
D-142	59.3 ± 13.7	14.7 ± 2.1	29.3 ± 7.9
D-168	85.2 ± 8.2	25.0 ± 8.4	25.5 ± 9.6
D-161	42.0 ± 3.3	29.1 ± 3.5	30.5 ± 7.8
Fluoxetine	1,092 ± 98	12.2 ± 2.4	713 ± 337
Reboxetine	2,908 ± 136	503 ± 61	0.79 ± 0.25
Desipramine	ND^b	135 ± 62	1.45 ± 0.24

Uptake into rat brain synaptosomes was measured as described in Methods. Results are average ± S.E.M. for 3 to 6 independent determinations.

not determined in this set of experiments.