Table 4.
Manipulation | Effect | |
---|---|---|
CB1 receptor | CB1 knockout | Reduced alcohol conditioned place preference |
Reduced alcohol preference and consumption | ||
Absence of alcohol-induced increase in NAc dopamine | ||
Increased sensitivity to intoxication | ||
Increased withdrawal | ||
CB1 antagonists | Attenuate acquisition of alcohol consumption | |
Reduce alcohol preference and consumption | ||
Attenuate alcohol-induced increases in NAc dopamine | ||
CB1 agonists | WIN 55,212-2 and CP 55,940 increase the motivation for and quantity of alcohol consumption |
|
eCB clearance inhibition | FAAH knockout | Increased alcohol preference and consumption |
Rats selectively bred for high alcohol preference |
Decreased FAAH expression and activity in PFC | |
Pharmacological Manipulations |
URB597 increases alcohol preference and consumption in mice, but not rats |
|
AM404 decreases alcohol consumption in rats | ||
Alcohol-induced alterations in brain eCB function |
Increased 2-AG and AEA formation in culture | |
Regionally distinct alterations in brain tissue eCB content | ||
Alcohol self-administration increases interstitial levels of 2- AG but not AEA in the NAc |
||
Decreased CB1 expression and function by chronic alcohol |