Table 7.
Manipulation | Effect | |
---|---|---|
CB1 receptor | CB1 knockout | Unaltered cocaine place preference |
Modest or no change in cocaine self-administration | ||
CB1 antagonists | AM251, but not SR141716A, decreases cocaine self- administration |
|
AM251 decreases methamphetamine self-administration | ||
AM251, but not SR141716A, decreases cocaine-induced facilitation of brain stimulation reward |
||
SR141716A does not alter cocaine-induced increases in NAc dopamine |
||
CB1 agonists | WIN 55,212-2 reduces cocaine self-administration and blocks cocaine-induced facilitation of brain stimulation reward |
|
eCB clearance inhibition | Pharmacological Manipulations |
URB597 does not alter cocaine self-administration |
URB597 does not modulate cocaine-induced alterations in VTA dopamine cell activity |
||
AM404 attenuates cocaine-induced facilitation of brain stimulation reward |
||
Cocaine-induced alterations in brain eCB function |
Tissue eCB content unaltered by chronic cocaine exposure | |
Cocaine self-administration does not alter interstitial eCB levels in the NAc |
||
Extended periods of cocaine self-administration result in increased levels of phosphorylated and total CB1 protein in the NAc and amygdala |