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. Author manuscript; available in PMC: 2012 Dec 1.
Published in final edited form as: Pharmacol Ther. 2011 Jul 18;132(3):215–241. doi: 10.1016/j.pharmthera.2011.06.005

Table 7.

Endocannabinoid influence on psychostimulant-related behaviors

Manipulation Effect
CB1 receptor CB1 knockout Unaltered cocaine place preference
Modest or no change in cocaine self-administration
CB1 antagonists AM251, but not SR141716A, decreases cocaine self-
administration
AM251 decreases methamphetamine self-administration
AM251, but not SR141716A, decreases cocaine-induced
facilitation of brain stimulation reward
SR141716A does not alter cocaine-induced increases in
NAc dopamine
CB1 agonists WIN 55,212-2 reduces cocaine self-administration and
blocks cocaine-induced facilitation of brain stimulation
reward
eCB clearance inhibition Pharmacological
Manipulations		 URB597 does not alter cocaine self-administration
URB597 does not modulate cocaine-induced alterations in
VTA dopamine cell activity
AM404 attenuates cocaine-induced facilitation of brain
stimulation reward
Cocaine-induced alterations in
brain eCB function		 Tissue eCB content unaltered by chronic cocaine exposure
Cocaine self-administration does not alter interstitial eCB
levels in the NAc
Extended periods of cocaine self-administration result in
increased levels of phosphorylated and total CB1 protein in
the NAc and amygdala