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. Author manuscript; available in PMC: 2012 Oct 11.
Published in final edited form as: Nat Commun. 2011 Oct 11;2:493. doi: 10.1038/ncomms1504

Figure 3. Transitions between multiple states in single-molecule trajectories.

Figure 3

(a) Transition density map constructed from the 0.65 M GdmCl data set. The map is a two-dimensional density plot of transitions identified by the change-point algorithm, as a function of initial and final FRET efficiencies for each transition. Note the strong deviation of the transition map from that expected for a two-state folder, which should include only two major peaks. (b) Correlation between the transition density map based on change-point analysis and maps based on the HMM analysis with an increasing number of states. The optimal number of states is found to be 5–7.