Table 1.

Significance gene changes associated with across-the-shift urinary 1-hydroxypyrene levels in 16 coke-oven workers (COW) and in 5 nonsmoking COW.

				16 COW			5 nonsmoking COW
	Gene name	Gene symbol	Location	Ra	p-value	FDRb	Ra	p-value
1	Myosin XVB	MYO15B	17q25.1	-0.862	< 1e-07	< 1e-07	-0.700	0.188
2	Solute carrier family 25, member 34	SLC25A34	1p36.21	-0.885	< 1e-07	< 1e-07	-0.500	0.391
3	DAZ associated protein 1	DAZAP1	19p13.3	-0.912	< 1e-07	< 1e-07	-0.900	0.037
4	GTPase, IMAP family member 6	GIMAP6	7	0.847	0.00001	0.0519	0.600	0.285
5	Prostaglandin reductase 1	PTGR1	9q31.3	0.835	0.0001	0.2130	0.900	0.037
6	Zinc finger protein 335	ZNF335	20q13.12	-0.826	0.0001	0.2780	-0.500	0.391
7	Spinster homolog 3 (Drosophila)	SPNS3	17p13.2	-0.826	0.0001	0.2780	-0.800	0.104
8	Homo sapiens genomic DNA, chromosome 11 clone: RP11-810P12, complete sequence	AP003733.5	11	0.818	0.0002	0.3060	0.500	0.391
9	ADP-ribosylation factor GTPase activating protein 2	ARFGAP2	11p11.2-p11. 12	-0.818	0.0002	0.3060	-0.700	0.188
10	Additional sex combs like 2	ASXL2	2p24.1	-0.818	0.0002	0.3060	-0.600	0.285
11	Vomeronasal 1 receptor 4	VN1R4	19q13.42	-0.803	0.0003	0.5070	-1.000	<0.001
12	PHD finger protein 2	PHF2	9q22.31	0.788	0.0004	0.6630	0.600	0.285
13	Apoptosis-inducing factor, mitochondrion-associated, 3	AIFM3	22q11.21	-0.785	0.0005	0.6630	-0.900	0.037
14	Chromosome 1 open reading frame 91	C1orf91	1p36.11-p34.2	-0.785	0.0005	0.6630	-0.600	0.285
15	Chromosome 2 open reading frame 66	C2orf66	2q33.1	-0.785	0.0005	0.6630	-0.700	0.188
16	Histone cluster 1, H2bi Solute carrier family 12	HIST1H2BI	6p21.3	-0.779	0.0006	0.6750	-0.900	0.037
17	(potassium/chloride transporters), member 7	SLC12A7	5p15	-0.779	0.0006	0.6750	-0.800	0.104
18	Claudin 15	CLDN15	7q11.22	-0.776	0.0006	0.6750	-0.700	0.188
19	Endoplasmic reticulum protein 27	ERP27	12p12.3	-0.776	0.0006	0.6750	-0.900	0.037
20	Intersection 2	ITSN2	2pter-p25.1	0.771	0.0007	0.7070	0.600	0.285
21	E4F transcription factor 1	E4F1	16p13.3	-0.771	0.0007	0.7070	-1.000	<0.001
22	Chromosome 17 open reading frame 70	C17orf70	17q25.3	-0.765	0.0009	0.7070	-0.700	0.188
23	NIPA-like domain containing 4	NIPAL4	5q33.3	0.762	0.0009	0.7070	0.900	0.037
24	Low density lipoprotein receptor-related protein 12	LRP12	8q22.2	-0.759	0.0010	0.7070	-0.800	0.104
25	Retinitis pigmentosa 11	RP11-399K21. 6	19q13.4	0.759	0.0010	0.7070	0.200	0.747
26	Hydroxyacylglutathione hydrolase-like	HAGHL	16p13.3	-0.759	0.0010	0.7070	-0.800	0.104

^aR: Spearman correlation coefficient

^bFDR: false discovery rate.