TABLE 4.
Hemodynamic assessment of diabetic rats treated with taurine, arginine and carnitine alone or in combination
| +dP/dt, mmHg/s | –dP/dt, mmHg/s | LVSP, mmHg | LVEDP, mmHg | |
|---|---|---|---|---|
| Control | 6866±248 | 5848±125 | 142±11 | 5.5±0.8 |
| Diabetes | 5182±161* | 3599±286* | 108±8* | 4.8±0.6 |
| Diabetes + taurine | 6367±286† | 4263±143*† | 113±5* | 4.9±0.7 |
| Diabetes + arginine | 5364±230* | 3000±233* | 105±6* | 4.1±0.9 |
| Diabetes + carnitine | 4963±109* | 3192±182* | 103±11* | 5.3±0.8 |
| Diabetes + combination | 5211±187* | 3187±122* | 101±12* | 4.8±0.8 |
Data presented as mean ± SE of six to eight animals for each group. Treated diabetic rats were also pretreated with amino acids for three weeks before streptozotocin injection.
*
P<0.05 versus control value;
†
P<0.05 versus nontreated diabetes value. +dP/dt Rate of contraction; –dP/dt Rate of relaxation; LVEDP Left ventricular end diastolic pressure; LVSP Left ventricular systolic pressure