Figure 3).

Myocardial ischemic tolerance in isolated Langendorff-perfused hearts of spontaneously hypertensive (SHR) and normotensive Wistar Kyoto control (C) rats subjected to 25 min global ischemia and 40 min reperfusion (A to C) or 30 min ischemia and 2 h reperfusion (D). A, B Timecourse of postischaemic recovery of left ventricular developed pressure (LVDP) and left ventricular end-diastolic pressure (LVEDP) expressed as a percentage of preischemic values and mmHg, respectively. C Incidence of sustained ventricular fibrillation (VF) expressed as a percentage. D Size of myocardial infarction. Infarct size (IS) area is expressed as a percentage of the area at risk (ie, IS area/LV area). Data presented as mean ± SEM of eight to 10 hearts per group. *P<0.05 versus normotensive control group