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. 2011 Nov;134(3):246–256. doi: 10.1111/j.1365-2567.2011.03485.x

Figure 3.

Figure 3

Different trafficking routes proposed for agonist-treated CCR5. Following agonist-stimulation, internalized CCR5 receptors are transported through the early endocytic pathway towards recycling and avoiding degradation. However, there are suggestions that the route followed by CCR5 may be ligand-dependent, as summarized here for the chemokine CCL5 and three of its derivatives.