Skip to main content
. Author manuscript; available in PMC: 2011 Nov 7.
Published in final edited form as: Handb Exp Pharmacol. 2011;(204):251–277. doi: 10.1007/978-3-642-17969-3_11

Fig. 4.

Fig. 4

Sildenafil reduces pulmonary hypertension associated with oxygen-induced BPD. (a) Right ventricular hypertrophy. Hyperoxia-exposed rats had significant right ventricular hypertrophy (RVH) as indicated by the increase in RV/LV+S ratio compared with normoxic controls. Sildenafil treatment reduced RVH (sildenafil 100 mg/kg subcutaneously daily during hyperoxia exposure). (b) Medial wall thickness. A representative picture of pulmonary arteries is shown displaying a thickened medial arterial wall in hyperoxic rat lungs as compared with normoxic controls. Sildenafil treatment significantly reduced the % medial wall thickness as compared with untreated hyperoxic pulmonary arteries (sildenafil 100 mg/kg subcutaneously daily during hyperoxia exposure). Reprinted with permission of the American Thoracic Society. Copyright American Thoracic Society; Ladha et al. (2005); Official Journal of the American Thoracic Society, Diane Gern, Publisher