Figure 5.

Time course study of the alterations in pro-inflammatory cytokines TNF-α, TGF-β, IL-6 and PDGF levels in sera and liver total cell extracts as well as NF-κB in total cell extracts of TAA-induced versus human MNCs-treated rats. Our results indicated significant elevation (p< 0.05) in TNF-α, TGF-β (a & b), IL-6 and PDGF levels (c &d) (p< 0.05) during the course of TAA-administration. Human MNCs injection induced HSCs apoptosis and significantly reduced (p<0.05) their levels at weeks 22 and 24. e) Data indicate significant elevation (p<0.05) in NF-κB during the follow up period of cirrhosis development and MNCs injection showed significant reduction (p <0.05) in NF-κB at weeks 22 and 24.* used to indicate the significance from control, and ** to indicate the significance between groups.