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. 2011 Nov;4(6):733–745. doi: 10.1242/dmm.008698

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© 2011. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial Share Alike License (http://creativecommons.org/licenses/by-nc-sa/3.0), which permits unrestricted non-commercial use, distribution and reproduction in any medium provided that the original work is properly cited and all further distributions of the work or adaptation are subject to the same Creative Commons License terms.

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Fig. 3. — The general model of intake regulation. This model is from de Castro and Plunkett (de Castro and Plunkett, 2002). In the model, intake (I) is controlled by two sets of factors, labelled as uncompensated (U_i; primarily environmental) and compensated (C_i; primarily physiological) factors. A key difference between these types of factors is that compensated factors have negative feedback loops with intake, simultaneously affecting and being affected by intake, whereas uncompensated factors affect intake, but are not affected by intake. Inheritance affects the system by determining: the preferred level for intake and compensated and uncompensated factors; the level of impact of the compensated (W_C_i) and uncompensated (W_U_i) factors on intake; and also the level of impact of intake minus expenditure (I–E) on compensated factors (i.e. W_F_i; the weighting factor). The model combines the concepts of negative feedback inherent in the set point model and uncompensated factors inherent in the settling point model.