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. 2011 Jun 30;4(6):842–849. doi: 10.1242/dmm.007948

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© 2011. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial Share Alike License (http://creativecommons.org/licenses/by-nc-sa/3.0), which permits unrestricted non-commercial use, distribution and reproduction in any medium provided that the original work is properly cited and all further distributions of the work or adaptation are subject to the same Creative Commons License terms.

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Fig. 4. — Expression analysis reveals potential mechanisms of insulin resistance at the transcriptional level in high-sugar-fed Drosophila. RNA was isolated from male control and high-sugar-fed Canton-S L3 larvae. Affymetrix GeneChips (Drosophila 2.0) were used to analyze gene expression. (A) Gene expression that changed more than 1.3-fold upon high-sugar feeding. The intersection of 12-hour and chronically high-sugar-fed datasets was modest, but significant for both up- and down-regulated genes; P<0.001 by a Pearson’s χ² test; n=3 for each condition. (B) Gene expression changes that are consistent with known mechanisms of metabolic homeostasis or insulin resistance. Fold changes are only reported if statistically significant probe intensity differences exist; P<0.05 via unpaired two-tailed t-test. nc, no change.