Table 1.
Baseline Characteristics of Peripheral Artery Disease Patients by quartiles of Red Cell Distribution Width
| Quartiles | ||||
|---|---|---|---|---|
| 1 | 2 | 3 | 4 | |
| Variable | (n=3008) | (n=3378) | (n=3273) | (n=3380) |
| Age (years) | 67.8 (12.9%) | 69.4 (11.9%) | 70.6 (11.3%) | 70.4 (11.6%) |
| Men | 1758 (58.4%) | 2134 (63.2%) | 2014 (61.5%) | 2039 (60.3%) |
| Body-mass index (kg/cm2) | 28.5 (5.1%) | 28.9 (5.4%) | 29.4 (5.8%) | 29.2 (6.6%) |
| Low ankle-brachial index | 2482 (82.5%) | 2729 (80.8%) | 2550 (77.9%) | 2326 (68.8%) |
| High ankle-brachial index | 526 (17.5%) | 649 (19.2%) | 723 (22.1%) | 1054 (31.2%) |
| Risk factors | ||||
| *Dyslipidemia | 2336 (77.7%) | 2646 (78.3%) | 2577 (78.7%) | 2573 (76.1%) |
| Hypertension | 2132 (70.9%) | 2506 (74.2%) | 2527 (77.2%) | 2543 (75.2%) |
| Diabetes | 960 (31.9%) | 1070 (31.7%) | 1178 (36.0%) | 1416 (41.9%) |
| Smoking | 2079 (79.3%) | 2494 (82.8%) | 2388 (80.5%) | 2392 (79.6%) |
| Comorbidities | ||||
| *Cerebrovascular disease | 910 (30.3%) | 1078 (31.9%) | 1053 (32.2%) | 1035 (30.6%) |
| Coronary heart disease | 1480 (49.2%) | 1826 (54.1%) | 1926 (58.9%) | 2051 (60.7%) |
| Heart failure | 267 (8.9%) | 386 (11.4%) | 539 (16.5%) | 969 (28.7%) |
| Chronic obstructive pulmonary disease |
408 (13.6%) | 530 (15.6%) | 580 (17.7%) | 647 (19.2%) |
| Chronic kidney disease | 141 (4.7%) | 202 (6.0%) | 317 (9.7%) | 644 (19.1%) |
| *Malignancy | 536 (17.8%) | 669 (19.8%) | 703 (21.5%) | 729 (21.6%) |
| Medications | ||||
| *Aspirin use | 1345 (44.7%) | 1549 (45.9%) | 1546 (47.2%) | 1556 (46.0%) |
| Statin use | 1021 (33.9%) | 1283 (38.0%) | 1306 (39.9%) | 1300 (38.5%) |
| Lab variables | ||||
| Red cell distribution width (%) | 12.3 (0.3) | 13.1 (0.2) | 13.9 (0.3) | 16.2 (2.1) |
| Erythrocyte count (1012/L) | 4.3 (0.5) | 4.3 (0.6) | 4.2 (0.6) | 4.1 (0.7) |
| Mean corpuscular volume (fL) | 92.0 (4.1) | 91.6 (4.5) | 90.9 (5.0) | 89.3 (8.1) |
| Hemoglobin (g/dL) | 13.5 (1.6) | 13.5 (1.7) | 13.1 (1.8) | 12.1 (1.9) |
| Creatinine (mg/dL) | 1.2 (0.5) | 1.3 (0.6) | 1.7 (0.7) | 1.7 (1.5) |
| eGFR (ml/min/1.73cm2) | 62.1 (18.0) | 60.9 (17.8) | 58.1 (19.4) | 53.6 (24.3) |
Continuous variables are expressed as mean (standard deviation); categorical variables are expressed as n (%); age, sex and body mass index adjusted the measures across the quartiles are significant at P < 0.01, except for the variables marked with *; coronary heart disease was defined as history of myocardial infarction, documented angina, abnormal stress test or coronary revascularization.