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. Author manuscript; available in PMC: 2011 Nov 7.
Published in final edited form as: Chem Biol Drug Des. 2009 Dec 17;75(2):143–151. doi: 10.1111/j.1747-0285.2009.00921.x

Table 1.

Binding Thermodynamics of Inhibitors

R1=R2 ΔG(cal/mol) ΔH(cal/mol) −TΔS(cal/mol) Kd(nM)
KNI-10769 H −10815±33 −4487±182 −6328±33 11.8±0.66
KNI-10265 F −11543±110 −6075±471 −5440±110 3.45±0.69
KNI-10074 Cl −12691±284 −6424±422 −6181±284 0.52±0.24
KNI-10006 CH3 −13490±185 −6475±668 −7015±185 0.14±0.04