Fig 1.

Copy-number abnormalities in diffuse intrinsic pontine glioma (DIPG). (A) Heat map showing segmentation analysis of normalized data from Affymetrix SNP 6.0 arrays to identify copy-number gains (red) and losses (blue) in 43 DIPGs and eight brainstem low-grade gliomas (LGGs). Chromosome positions are indicated along y-axis and separated by dashed line. Histologic subtypes are indicated across top. Scale bar shows color gradient to indicate copy number. Comparison of frequencies of most common large-scale genomic (B) gains or (C) losses in DIPG, compared with adult¹⁴ or pediatric nonbrainstem glioblastoma (GBM).⁶ Large-scale gains or losses were scored when more than half of markers on chromosome arm had copy-number gains or losses, respectively. All frequencies and P values listed in Data Supplement. (*) Indicates tumors obtained before adjuvant therapy.