Table 1.

Recurrent Focal Gains of RTKs and Cell-Cycle Regulatory Genes

Tumor No.	RB Signaling					RTK-Ras-PI3K-Akt Signaling Network												PI3K Class 2PIKC2G
	CDK4	CDK6	CCND1	CCND2	CCND3	EGFR	ERBB4	PDGFRA	MET	HGF	IGF1R	IGF2	KRAS	NF1	AKT1	AKT3	PI3KCA
BSG001T				Gain	Gain				Gain									Gain
BSG003T(BS)		Gain					Gain	Gain	Gain	Gain	Gain
BSG003T(CB)								Gain			Gain
BSG009T								Gain	Gain*		Gain*
BSG010T				Gain
BSG019T		Gain						Gain			Gain
BSG020T	Gain															Gain
BSG022TD					Gain
BSG023T								Gain*	Gain		Gain*
BSG024T						Gain		Gain
BSG024TD											Gain	Gain
BSG025T								Gain*
BSG027TD	Gain
BSG035T		Gain					Gain	Gain	Gain
BSG037T	Gain						Gain	Gain	Gain*							Gain
BSG039T		Gain	Gain			Gain			Gain
BSG040T				Gain
BSG044T			Gain					Gain			Gain						Gain
BSG045T								Gain*
BSG046T														Deletion
BSG047T								Gain*	Gain*
BSG509T								Gain	Gain*		Gain*
BSG529T									Gain*
BSG902TD		Gain							Gain	Gain			Gain		Gain			Gain
Frequency, %	7.0	11.6	4.7	7.0	4.7	4.7	7.0	30.2	25.6	4.7	18.6	2.3	2.3	2.3	2.3	4.7	2.3	4.7

Abbreviations: FISH, fluorescent in situ hybridization; PI3K, phosphoinositide 3-kinase; RB, retinoblastoma protein; RTK, receptor tyrosine kinase.

^*Gain identified by FISH.