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. Author manuscript; available in PMC: 2012 Oct 27.
Published in final edited form as: J Med Chem. 2011 Sep 22;54(20):7150–7164. doi: 10.1021/jm200739e

Figure 1.

Figure 1

Structures for classical antifolates and novel pyrrolo- and thieno[2,3-d]pyrimidine antifolates. Compounds 4–8 were previously described12–14. MTX is a dihydrofolate reductase inhibitor, whereas PMX and RTX are primarily thymidylate synthase inhibitors. Compound 9 is a novel antifolate and dihydrofolate reductase inhibitor16 that is an active and highly selective substrate for RFC over PCFT6,15.