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. Author manuscript; available in PMC: 2012 Oct 27.
Published in final edited form as: J Med Chem. 2011 Sep 22;54(20):7150–7164. doi: 10.1021/jm200739e

Figure 2.

Figure 2

Structures for previous generation GARFTase inhibitors. Lometrexol was originally synthesized by Taylor et al.17 and the first antifolate inhibitor of GARFTase18,19. Compounds 10a and 10b are second generation GARFTase inhibitors as described in the text20–22.