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. Author manuscript; available in PMC: 2012 Oct 27.
Published in final edited form as: J Med Chem. 2011 Sep 22;54(20):7150–7164. doi: 10.1021/jm200739e

Figure 6. Protection of R2/hPCFT4 cells from growth inhibition by the 6-substituted pyrrolo[2,3-d] pyrimidine thienoyl antifolate 3 (upper) and PMX (lower) in the presence of nucleosides and 5-amino-4-imidazolecarboxamide (AICA).

Figure 6

Proliferation inhibition was measured for R2/hPCFT4 cells over a range of concentrations of compound 3, in the presence or absence of adenosine (60 µM), thymidine (10 µM), and/or AICA (320 µM), as described in the Experimental Section. Results were normalized to cell density in the absence of drug. Results shown are representative data from experiments performed in triplicate.