. Author manuscript; available in PMC: 2012 Nov 15.

Published in final edited form as: Bioorg Med Chem Lett. 2011 Sep 20;21(22):6739–6745. doi: 10.1016/j.bmcl.2011.09.049

Table 1. S1P₄–R agonist activity of compounds 15a-15n (EC₅₀ nM).

cpd	R²	R¹	X	EC₅₀ (nm)^α
15a	NMe	H	S	3600
15b	NH	H	S	NA
15c	NPh	Me	S	2800
15d	NPh	H	S	NA
15e	N(pyridin-2-yl)	H	S	2100 (70%) ^β
15f	O	Me	S	NA
15g	NEt	Et	S	250
15h	NCH₂CH₂OH	Me	S	306
15i	NMe	Me	O	NA
15j	NCH₂CH₂CH₂		S	NA
15k	NCH₂CH₂		S	NA
15l	NiPr	iPr	S	NA
15m	NnPr	nPr	S	NA
15n	NnBu	nBu	S	NA

^α

Data are reported as mean of n = 3 determinations.

^β

Percentage of response.

NA = not active at concentrations up to 25 μM.

Table 1. S1P4–R agonist activity of compounds 15a-15n (EC50 nM).