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. 2011 Sep 13;30(19):3962–3976. doi: 10.1038/emboj.2011.328

Figure 6.

Figure 6

Comparison of DHS sites in parental and FoxA1-depleted LNCaP-1F5 cells. (A) DHS sites together with AR- and FoxA1-binding sites in parental and siFoxA1 cells at the NKX3-1 and DBI loci. The constitutively open sites are shown marked by red arrows. (B) DHS sites together with AR- and FoxA1-binding sites in parental and siFoxA1 cells at the EDN2 and PTGES loci. The de novo DHS sites are marked by green arrows. EDN2 and PTGES genes are androgen-regulated only in siFoxA1 cells. (C) Proportion of the DHS sites in the three ARB classes defined by FoxA1. DHS sites for FoxA1-independent ARBs are shown separately for parental (P) and FoxA1-depleted cells (F).