Table 3. Sex-stratified adjusted mean forced expiratory volume in 1 s% predicted values across quartiles of metabolic biomarkers among participants with normal glucose tolerance in the Jackson heart study, 2000–2004.
| Women (n = 1.445) | Men (n = 654) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Quartile 1 | Quartile 2 | Quartile 3 | Quartile 4 | p for trend | Quartile 1 | Quartile 2 | Quartile 3 | Quartile 4 | p for trend | |
| Glucose (mg/dl) | (68–82) | (83–86) | (87–91) | (92–99) | (71–84) | (85–88) | (89–92) | (93–99) | ||
| Model 1 | 95.1 (93.4–96.8) | 96.3 (94.5–98.2) | 97.0 (95.3–98.6) | 93.7 (92.1–95.4) | 0.039 | 94.9 (92.6–97.2) | 93.8 (91.5–96.1) | 91.7 (89.3–94.1) | 92.3 (90.1–94.5) | 0.217 |
| Model 2 | 94.2 (92.5–95.9) | 96.3 (94.4–98.1) | 97.2* (95.6–98.8) | 94.4 (92.8–96.1) | 0.037 | 94.3 (92.0–96.7) | 93.8 (91.5–96.0) | 91.8 (89.4–94.2) | 92.8 (90.6–95.0) | 0.459 |
| Insulin (μU/l) | (1–9) | (10–13) | (14–18) | (19–105) | (1–9) | (10–12) | (13–17) | (18–50) | ||
| Model 1 | 97.5 (95.6–99.5) | 96.3 (94.7–97.9) | 95.5 (93.8–97.1) | 93.0*** (91.3–94.8) | 0.005 | 95.4 (93.1–97.6) | 94.3 (92.1–96.6) | 94.4 (92.2–96.7) | 88.4*** (86.1–90.7) | <0.001 |
| Model 2 | 95.8 (93.8–97.8) | 95.9 (94.3–97.4) | 95.7 (94.0–97.3) | 94.7 (92.9–96.5) | 0.802 | 94.8 (92.4–97.1) | 94.0 (91.7–96.3) | 94.6 (92.3–96.9) | 89.1** (86.6–91.6) | 0.005 |
| Insulin resistance | (0.189–2.161) | (2.162–2.922) | (2.923–4.027) | (4.028–25.009) | (0.179–2.014) | (2.015–2.681) | (2.682–3.840) | (3.841–10.949) | ||
| Model 1 | 97.5 (95.9–99.2) | 95.8 (94.0–97.5) | 95.4 (93.7–97.1) | 93.3*** (91.6–95.0) | 0.009 | 95.4 (93.1–97.6) | 94.5 (92.3–96.8) | 94.1 (91.9–96.4) | 88.7*** (86.4–91.0) | <0.001 |
| Model 2 | 96.0 (94.3–97.8) | 95.3 (93.6–97.0) | 95.8 (94.1–97.5) | 94.9 (93.1–96.7) | 0.812 | 94.8 (92.4–97.2) | 94.2 (91.9–96.5) | 94.3 (92.0–96.5) | 89.4** (86.9–91.9) | 0.011 |
| HbA1c (%) | (3.6–5.1) | (5.2–5.4) | (5.5–5.7) | (5.8–7.6) | (3.6–5.1) | (5.2–5.4) | (5.5–5.7) | (5.8–7.9) | ||
| Model 1 | 96.9 (95.1–98.6) | 97.1 (95.3–98.9) | 94.4* (92.8–96.0) | 93.8* (92.1–95.6) | 0.016 | 93.8 (91.5–96.2) | 94.8 (92.4–97.2) | 94.1 (91.9–96.2) | 90.3* (87.9–92.6) | 0.038 |
| Model 2 | 96.0 (94.3–97.8) | 96.7 (95.0–98.5) | 94.6 (93.0–96.3) | 94.8 (93.0–96.6) | 0.281 | 93.4 (91.0–95.7) | 94.6 (92.2–96.9) | 94.2 (92.0–96.3) | 90.8 (88.4–93.1) | 0.109 |
HbA1c hemoglobin A1c
Model 1 adjusts for education, annual household income, physical activity, and respiratory medication use. Model 2 adjusts for the variables in Model 1 plus waist circumference. Participants in quartile 1 served as the referent group
†P < 0.10;
*
< 0.05;
**
P < 0.01;
***
P < 0.001