Table 4. Sex-stratified adjusted mean forced expiratory volume in 6 s% predicted values across quartiles of metabolic biomarkers among participants with normal glucose tolerance in the Jackson heart study, 2000–2004.
| Women (n = 1.445) | Men (n = 654) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Quartile 1 | Quartile 2 | Quartile 3 | Quartile 4 | p for trend | Quartile 1 | Quartile 2 | Quartile 3 | Quartile 4 | p for trend | |
| Glucose (mg/dl) | (68–82) | (83–86) | (87–91) | (92–99) | (71–84) | (85–88) | (89–92) | (93–99) | ||
| Model 1 | 94.2 (92.6–95.8) | 95.3 (93.5–97.1) | 97.0* (95.4–98.6) | 93.6 (92.0–95.2) | 0.017 | 93.9 (91.6–96.2) | 93.1 (90.8–95.3) | 91.8 (89.5–94.2) | 91.6 (89.5–93.8) | 0.447 |
| Model 2 | 93.2 (91.5–94.8) | 95.2 (93.5–96.9) | 97.3*** (95.7–98.8) | 94.4 (92.8–96.0) | 0.004 | 93.2 (90.9–95.4) | 93.0 (90.8–95.2) | 92.0 (89.6–94.3) | 92.3 (90.1–94.4) | 0.870 |
| Insulin (μU/l) | (1–9) | (10–13) | (14–18) | (19–105) | (1–9) | (10–12) | (13–17) | (18–50) | ||
| Model 1 | 97.3 (95.4–99.1) | 96.4 (94.9–98.0) | 94.9 (93.4–96.5) | 91.8*** (90.1–93.4) | <0.001 | 95.9 (93.7–98.0) | 93.7 (91.5–95.9) | 93.6 (91.3–95.8) | 86.9*** (84.6–89.2) | <0.001 |
| Model 2 | 95.3 (93.3–97.2) | 95.9 (94.4–97.4) | 95.2 (93.6–96.7) | 93.7 (92.0–95.4) | 0.328 | 95.1 (92.8–97.3) | 93.3 (91.1–95.5) | 93.8 (91.6–96.0) | 87.9*** (85.5–90.4) | <0.001 |
| Insulin resistance | (0.189–2.161) | (2.162–2.922) | (2.923–4.027) | (4.028–25.009) | (0.179–2.014) | (2.015–2.681) | (2.682–3.840) | (3.841–10.949) | ||
| Model 1 | 97.1 (95.5–98.8) | 96.0 (94.4–97.7) | 94.7* (93.0–96.3) | 92.2*** (90.6–93.9) | <0.001 | 95.6 (93.4–97.8) | 94.3 (92.1–96.5) | 93.2* (91.0–95.4) | 87.2*** (85.0–89.4) | <0.001 |
| Model 2 | 95.4 (93.7–97.1) | 95.5 (93.8–97.1) | 95.1 (93.5–96.8) | 94.1 (92.4–95.8) | 0.686 | 94.8 (92.5–97.1) | 93.9 (91.7–96.1) | 93.4 (91.2–95.6) | 88.2*** (85.8–90.7) | 0.001 |
| HbA1c (%) | (3.6–5.1) | (5.2–5.4) | (5.5–5.7) | (5.8–7.6) | (3.6–5.1) | (5.2–5.4) | (5.5–5.7) | (5.8–7.9) | ||
| Model 1 | 97.3 (95.6–98.9) | 96.4 (94.7–98.0) | 93.6** (92.0–95.1) | 92 8*** (91.1–94.5) | <0.001 | 93.5 (91.2–95.8) | 94.3 (92.0–96.7) | 93.3 (91.2–95.4) | 89.4* (87.1–91.7) | 0.016 |
| Model 2 | 96.3 (94.6–97.9) | 95.9 (94.3–97.6) | 93.9* 92.3–95.4) | 93.9† (92.2–95.6) | 0.077 | 93.0 (90.7–95.2) | 94.0 (91.7–96.3) | 93.4 (91.3–95.5) | 90.0(87.7–92.3) | 0.085 |
HbA1c hemoglobin A1c
Model 1 adjusts for education, annual household income, physical activity, and respiratory medication use. Model 2 adjusts for the variables in Model 1 plus waist circumference. Participants in quartile 1 served as the referent group
†
P < 0.10;
*
P < 0.05;
**
P < 0.01;
***
P < 0.001