Table 5. Sex-stratified adjusted mean forced vital capacity % predicted values across quartiles of metabolic biomarkers among participants with normal glucose tolerance in the Jackson heart study, 2000–2004.
| Women (n = 1.445) | Men (n = 654) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Quartile 1 | Quartile 2 | Quartile 3 | Quartile 4 | p for trend | Quartile 1 | Quartile 2 | Quartile 3 | Quartile 4 | p for trend | |
| Glucose (mg/dl) | (68–82) | (83–86) | (87–91) | (92–99) | (71–84) | (85–88) | (89–92) | (93–99) | ||
| Model 1 | 93.2 (91.5–94.8) | 94.2 (92.4–96.0) | 96.0* (94.4–97.6) | 92.7 (91.0–94.3) | 0.026 | 93.1 (90.7–95.4) | 92.4 (90.0–94.7) | 90.8 (88.4–93.2) | 90.5 (88.3–92.8) | 0.364 |
| Model 2 | 92.1 (90.5–93.8) | 94.1 (92.3–95.9) | 96.2*** (94.6–97.8) | 93.5 (91.9–95.1) | 0.005 | 92.3 (90.0–94.7) | 92.3 (90.0–94.6) | 90.9 (88.5–93.3) | 91.2 (89.0–93.4) | 0.784 |
| Insulin (μU/l) | (1–9) | (10–13) | (14–18) | (19–105) | (1–9) | (10–12) | (13–17) | (18–50) | ||
| Model 1 | 96.3 (94.4–98.2) | 95.5 (94.0–97.1) | 93.9 (92.3–95.5) | 90.6*** (88.9–92.3) | <0.001 | 94.9 (92.7–97.1) | 92.8 (90.5–95.1) | 92.7 (90.4–95.0) | 86.0*** (83.6–88.3) | <0.001 |
| Model 2 | 94.3 (92.3–96.2) | 95.0 (93.5–96.6) | 94.1 (92.5–95.7) | 92.6 (90.8–94.3) | 0.244 | 94.1 (91.7–96.4) | 92.4 (90.1–94.7) | 92.9 (90.6–95.2) | 87.0*** (84.5–89.5) | <0.001 |
| Insulin resistance | (0.189–2.161) | (2.162–2.922) | (2.923–4.027) | (4.028–25.009) | (0.179–2.014) | (2.015–2.681) | (2.682–3.840) | (3.841–10.949) | ||
| Model 1 | 96.1 (94.4–97.8) | 95.2 (93.6–96.9) | 93.6* (91.9–95.2) | 94.4*** (89.4–92.8) | <0.001 | 94.4 (92.2–96.7) | 93.7 (91.5–96.0) | 92.2* (89.9–94.5) | 86.2*** (83.9–88.5) | <0.001 |
| Model 2 | 94.3 (92.6–96.1) | 94.7 (93.0–96.3) | 94.0 (92.4–95.7) | 93.0 (91.3–94.7) | 0.594 | 93.6 (91.3–96.0) | 93.3 (91.0–95.6) | 92.4 (90.1–94.7) | 87.3*** (84.8–89.8) | 0.002 |
| HbA1c (%) | (3.6–5.1) | (5.2–5.4) | (5.5–5.7) | (5.8–7.6) | (3.6–5.1) | (5.2–5.4) | (5.5–5.7) | (5.8–7.9) | ||
| Model 1 | 96.4 (94.7–98.1) | 95.2 (93.5–96.9) | 92.4*** (90.8–94.0) | 91 7*** (89.9–93.4) | <0.001 | 92.6 (90.2–95.0) | 93.7 (91.3–96.1) | 92.3 (90.1–94.4) | 88.3* (85.9–90.7) | 0.012 |
| Model 2 | 95.4 (93.8–97.1) | 94.8 (93.1–96.5) | 92.7* (91.2–94.3) | 92.8* (91.1–94.5) | 0.048 | 92.1 (89.7–94.4) | 93.4 (91.0–95.8) | 92.4 (90.3–94.5) | 89.0† (86.6–91.3) | 0.064 |
HbA1c hemoglobin A1c
Model 1 adjusts for education, annual household income, physical activity, and respiratory medication use. Model 2 adjusts for the variables in Model 1 plus waist circumference. Participants in quartile 1 served as the referent group
†
P < 0.10;
*
P < 0.05;
**
P < 0.01;
***
P < 0.001