Table 2.
Representative Results Obtained From Linkage Analysisa
| Seroconversion event identification number |
|||||
| Linkage criterionb | 052-1692 | 052-2899 | 052-0621 | 052-3172 | 052-2377 |
| No. of available samples | 4 | 3 | 4 | 4 | 4 |
| Phylogenetic clustering | Grouped | Grouped | Grouped | Not grouped | Grouped |
| Bootstrap value | 100% | 100% | 100% | ND | 100% |
| Sequence similarity | 98.2–98.5 | 97.9–98.0 | 96.9–98.5 | 92.2 | 98.5 |
| Bayesian posterior probability, pooled | 1.00 | 0.99–1.00 | 0.94–1.00 | 0.00 | 1.00 |
| Bayesian posterior probability, unpooled | 1.00 | 1.00 | 0.99–1.00 | 0.00 | 1.00 |
| Final linkage assessment | Linked | Linked | Linked | Unlinked | Linked |
Results are shown from analysis of 5 seroconversion events from Africa (the same events included in Figure 2).
No. available sequences indicates the total number of index and partner samples available for the analysis of each seroconversion event; the number 4 indicates that samples were available for 2 different study visits for both the index and the partner. Phylogenetic clustering: “Grouped” indicates that all available index and partner sequences were grouped together on a single, unique branch. “Not grouped” indicates that the sequences from the partner did not group with the sequences from the index participant. Bootstrap values are for the grouping of index and partner sequences. A bootstrap value was not determined for the unlinked event (052-3172, not determined [ND]); that event was confirmed to be unlinked based on results from next-generation sequencing.