Figure 1.

Impact of high-dose valacylovir treatment on human immunodeficiency virus (HIV) transmission and the HIV epidemic. A, The reduction in HIV transmission probability per coital act expected with a reduction in HIV plasma viral load. The X marker signifies the reduction in infectiousness expected with a reduction of 1 log₁₀ copies/mL in HIV plasma viral load, similar to the viremia reduction observed by Mugwanya et al. B, Impact of intervention aimed at reducing community-level HIV plasma viral load on HIV prevalence and incidence rate at endemic equilibrium. The X marker signifies the impact on prevalence and incidence if the community-level viral load is reduced at the population level by similar magnitude to that observed in Mugwanya et al.