Table 2.
Disease Progression for Imaged and Nonimaged Nonhuman Primates
| Intravenous (5 × 106 PFU) |
Intrabronchial (5 × 105 PFU) |
|||
| Imaged (n = 2) | Nonimaged (n = 6)a | Imaged (n = 2) | Nonimaged (n = 6)a | |
| Mean day of fever onset | 3.5 | 3.0 | 6.0 | 7.0 |
| Temperature rangeb | 102.8–103.5 | 102.0–103.6 | 102.5–102.6 | 102.1–104.3 |
| Mean day of lesion appearance | 6.0 | 5.3 | 9.0 | 9.1 |
| Lesion rangec | 538–1215 | 134–661 | 182–235 | 13–615 |
| Mean day of peak viremia | 9.0 | 9.3 | 11.5 | 10.0 |
| Mean peak viremiad | 6.9 | 6.4 | 5.3 | 7.6 |
| Day of death | 12.0e | 15.0e | 17.0e | 9.0e |
Abbreviation: PFU, plaque-forming unit.
a
Historical data from Johnson et al [20].
b
Range of mean peak temperature (°F).
c
Range of peak lesion numbers.
d
Log10 gene copies/mL.
e
Only 1 animal met endpoint criteria.