Table 1.

mRNA fold change of synaptic, mitochondrial fission/fusion and peroxiredoxin genes in primary neurons from AβPP cultures relative to WT neurons

Synaptic		Peroxyredoxins		Mitochondrial dynamics/matrix
PSD-95	−1.5*	Prx1	−1.3	Fis1	1.5*
Synaptophysin	−2.0*	Prx2	−1.1	Drp1	1.1
Synapsin1	−1.5**	Prx3	−1.3	Mfn1	−1.6*
Synapsin2	−1.4**	Prx4	−1.2	Mfn2	−1.1
Synaptobrevin1	−1.3*	Prx5	−1.1	OPA-1	−1.3
Synaptobrevin2	−1.3*	Prx6	1.0	CypD	1.6**
GAP43	−1.2**
Neurogranin	1.0
Synaptopodin	−1.1

mRNA fold changes for synaptic genes, mitochondrial genes and peroxiredoxins were calculated. Gene expression was normalized to β-actin. n = 3 cultures per group.

*P ≤ 0.05, **P ≤ 0.01 compared with WT.