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. 2011 Aug 31;20(23):4582–4596. doi: 10.1093/hmg/ddr392

Figure 3.

Figure 3.

Progressive cardiomyopathy and fibrosis in Jup mutant mice. (A) H&E staining (a and e) and Sirius red-fast green staining (b–d and f–h) of 12-day-old hearts. (c, g) and (d, h) High magnification of RV and LV from (b) and (f), respectively. Bars (a, b, e, f), 0.5 mm; bars (c, d, g, h), 20 μm. (B) H&E staining (a and e) and Sirius red-fast green staining (b–d and f–h) of 18-day-old hearts. Fibrotic substitution [arrow in (f); arrowheads in (g)] is evident in Jup mutant RV. Bars (a, b, e, f), 0.5 mm; bars (c, d, g, h), 20 μm. (C) H&E staining (a and e) and Sirius red-fast green staining (b–d and f–h) of 30-day-old hearts. RA, RV and LV of a Jup mutant heart (e) was overtly enlarged compared to those of a littermate control heart (a). Sirius red-fast green staining demonstrates broad fibrosis (arrows in (f); arrowheads in (g, h)) in both RV (g) and LV (h). Bars (a, b, e, f), 0.6 mm; Bars (c, d, g, h), 30 μm.