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Exogenous GLU evokes activity-dependent inhibition of behavioral responses to heat. Intraplantar injection of 0.3 mm GLU alone, 20 μm LY alone, or vehicle does not produce any change in hindpaw thermal sensitivity. If 0.3 mm GLU is injected in the presence of 20 μm LY, there is a significant and prolonged effect on PWL (*p < 0.001, compared with 3 other groups; +p < 0.05, compared with baseline, two-way repeated-measures ANOVA followed by Tukey's test).
