Table 1. A list of 24 proteins showing significantly elevated interaction with the saliva autoantibodies in pSS patients compared with both SLE patients and healthy control subjects.
| Protoarray database ID |
Mean signal (pSS) |
Mean signal (SLE) |
Mean signal (Ctrl) |
Median signal (pSS) |
Median signal (SLE) |
Median signal (Ctrl) |
p-Value (pSS vs. SLE) |
p-Value (pSS vs. Ctrl) |
Protein description |
|---|---|---|---|---|---|---|---|---|---|
| BC069328.1 | 1159.0 | 477.0 | 927.0 | 1049.0 | 232.0 | 282.0 | 1.57E–02 | 1.57E–02 | Bcl2 modifying factor (BMF) |
| Cardiolipin | 13 678.1 | 4449.3 | 4743.2 | 8457.0 | 4288.5 | 4646.0 | 1.01E–02 | 2.14E–02 | Cardiolipin – known autoantigen |
| NM_022101.1 | 1345.7 | 228.3 | 505.7 | 1207.8 | 20.0 | 351.0 | 1.03E–03 | 4.77E–03 | Chromosome Xopen-reading frame 56 (CXorf56) |
| XM_375456.2 | 770.5 | 366.6 | 344.6 | 877.5 | 275.0 | 170.0 | 1.30E–02 | 1.30E–02 | Hypothetical protein DKFZp761G2113 |
| NM_018664.1 | 910.4 | 414.2 | 361.3 | 258.5 | 268.5 | 344.0 | 2.48E–02 | 2.48E–02 | Jun dimerization protein p21SNFT (SNFT) |
| La | 38 649.2 | 1137.0 | 9398.0 | 58 625.0 | 1026.0 | 621.5 | 4.27E–04 | 8.76E–03 | La/SS-B – known autoantigen |
| BC053667.1 | 2194.1 | 1229.6 | 1134.1 | 1779.0 | 1009.5 | 948.0 | 1.51E–02 | 1.51E–02 | Lectin, galactoside-binding, soluble, 3 (LGALS3) |
| NM_002307.1 | 2758.2 | 1288.9 | 1506.4 | 1899.0 | 1312.5 | 1110.5 | 1.01E–02 | 1.59E–02 | Lectin, galactoside-binding, soluble, 7 (LGALS7) |
| PV3370 | 28 635.8 | 11 573.2 | 16 783.6 | 23 728.8 | 11 057.0 | 15 405.0 | 1.35E–03 | 2.14E–02 | Megakaryocyte-associated tyrosine kinase (MATK) |
| BC032852.2 | 921.5 | 339.0 | 427.8 | 642.0 | 204.0 | 239.5 | 2.48E–02 | 2.48E–02 | Melanoma antigen, family B, 4 (MAGEB4) |
| NM_004527.2 | 2191.2 | 1366.1 | 1377.8 | 1641.8 | 1200.0 | 1343.0 | 2.48E–02 | 2.48E–02 | Mesenchyme homeo box 1 (MEOX1) |
| NM_024946.1 | 2326.8 | 3110.1 | 1106.6 | 2228.8 | 1430.0 | 1329.5 | 1.57E–02 | 1.30E–02 | NEFA-interacting nuclear protein NIP30 (NIP30) |
| AB065630.1 | 398.1 | 137.9 | 202.0 | 304.3 | 121.0 | 185.5 | 2.48E–02 | 2.48E–02 | Olfactory receptor, family 6, subfamily N, member 2 (OR6N2) |
| BC010629.1 | 3307.4 | 1750.5 | 2080.0 | 3015.5 | 1780.0 | 1889.5 | 2.79E–05 | 5.80E–03 | Outer dense fiber of sperm tails 2 (ODF2) |
| NM_015993.1 | 1641.6 | 487.8 | 856.9 | 1557.3 | 281.5 | 751.0 | 3.39E–05 | 5.30E–03 | Plasma membrane proteolipid (plasmolipin) (PLLP) |
| P2996 | 5900.6 | 3587.5 | 4452.8 | 5069.0 | 3324.0 | 3264.5 | 4.77E–03 | 1.57E–02 | Protein kinase C,6 (PRKCQ) |
| PV3831 | 7322.9 | 3455.0 | 3183.7 | 4050.3 | 3765.5 | 2670.0 | 2.48E–02 | 1.65E–02 | Ribosomal protein S6 kinase, polypeptide 2 (RPS6KB2) |
| Ro-52 | 35 279.6 | 1763.6 | 10 734.4 | 34 463.0 | 1519.5 | 1687.5 | 2.79E–05 | 4.77E–03 | Ro-52/SS-A – known autoantigen |
| BC034554.1 | 2469.5 | 891.0 | 856.8 | 1583.3 | 890.0 | 829.5 | 2.48E–02 | 8.76E–03 | Serpin peptidase inhibitor, clade A, member 3 (SERPINA3) |
| BC014051.1 | 4542.0 | 2655.1 | 1912.8 | 4172.3 | 2748.5 | 1712.0 | 1.01E–02 | 3.86E–03 | Small inducible cytokine subfamily E, member 1 (SCYE1) |
| BC028366.1 | 1521.2 | 714.8 | 778.2 | 1107.8 | 494.5 | 610.0 | 2.14E–02 | 2.48E–02 | Testis specific, 10 (TSGA10) |
| PV3652 | 9624.5 | 5903.6 | 4835.3 | 6823.5 | 4874.0 | 4265.0 | 2.48E–02 | 1.01E–02 | TAO kinase 3 (TAOK3) |
| Transglutaminase | 6714.2 | 1124.1 | 3584.5 | 5155.8 | 1075.5 | 516.5 | 1.19E–04 | 1.57E–02 | Transglutaminase – known autoantigen |
| Histone | 6077.4 | 2721.1 | 2300.6 | 3438.0 | 2509.5 | 2593.0 | 2.48E–02 | 2.14E–02 | Unfrac. Whole histone – known autoantigen |