Table 1.
E1-HVR1 intrapatient diversity for the serum and peripheral-blood mononuclear cell (PBMC) quasispecies from hepatitis C virus (HCV)–monoinfected and HCV/HIV-coinfected participants.
| Sample, patient, time point | Intrapatient genetic distance | Entropy | dN:dS |
|---|---|---|---|
| Serum compartment of HCV monoinfected | |||
| 11 | |||
| A | 2.19 | 0.47 | 0.43 |
| B | 1.41 | 0.59 | 0.40 |
| 15 | |||
| A | 0.51 | 0.14 | 0.15 |
| B | 2.51 | 0.35 | 0.67 |
| 20 | |||
| A | 0.88 | 0.41 | 0.35 |
| B | 0.60 | 0.59 | a |
| 25 | |||
| A | 0.32 | 0.41 | 1.00 |
| B | 1.50 | 0.56 | 9.50 |
|
| |||
| Serum compartment of HCV/HIV coinfected | |||
| 30 | |||
| A | 4.74 | 0.56 | 0.69 |
| B | 3.33 | 0.58 | 0.55 |
| C | 4.39 | 0.56 | 0.55 |
| 36 | |||
| A | 0.80 | 0.52 | 1.50 |
| B | 2.27 | 0.64 | 1.15 |
| C | 1.57 | 0.61 | 2.00 |
| 37 | |||
| A | 7.56 | 0.60 | 1.01 |
| B | 7.66 | 0.54 | 0.90 |
| C | 6.75 | 0.55 | 0.48 |
| 48 | |||
| A | 4.04 | 0.39 | 1.00 |
| B | 5.40 | 0.64 | 1.74 |
| C | No sample | No sample | No sample |
| 49 | |||
| A | 4.35 | 0.54 | 0.96 |
| B | 2.72 | 0.60 | 2.67 |
| C | 5.81 | 0.50 | 1.07 |
|
| |||
| PBMC compartment of HCV/HIV coinfected | |||
| 30 | |||
| A | 1.01 | 0.28 | 0.10 |
| B | 3.68 | 0.39 | 0.56 |
| C | 2.11 | 0.51 | 0.47 |
| 36 | |||
| A | 1.27 | 0.35 | 3.00 |
| B | 3.12 | 0.94 | 2.12 |
| C | 3.14 | 1.00 | 2.12 |
| 37 | |||
| A | 5.61 | 0.94 | 0.86 |
| B | 1.87 | 0.70 | 0.21 |
| C | 8.13 | 0.70 | 0.60 |
| 48 | |||
| A | 3.40 | 0.47 | 1.03 |
| B | 3.47 | 0.56 | 0.48 |
| C | 0.40 | 0.14 | 0.22 |
| 49 | |||
| A | 0.19 | 0.27 | a |
| B | 2.44 | 0.80 | 2.42 |
| C | 4.23 | 0.51 | 1.48 |
NOTE. dN, nonsynonymous; dS, synonymous.
a
Indicates that dS =0; therefore, this time point could not be defined.