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. Author manuscript; available in PMC: 2012 May 1.
Published in final edited form as: Nat Chem Biol. 2011 Sep 25;7(11):810–817. doi: 10.1038/nchembio.664

Figure 3.

Figure 3

a) Reaction sequence in the on-resin N-methylation of 1 and 2, and the resulting pattern of alkylation to generate 3 and 4, respectively. H/D exchange studies on 1 and 3 (b) along with 2 and 4 (c). Amide N-H resonances were monitored as a function of time after addition of 5% MeOH-d4/0.5% HOAc-d4.