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In vitro cell permeability, microsomal stability, and serum stability data for selected cyclic peptides.
| compound | RRCK pH 7.4(× 106cm/s) | HLM Clint (μg/min/mg) | RLM Clint (μg/min/mg) | Human plasma stab (t1/2, min) |
|---|---|---|---|---|
| CSA | 1.1 | 46.8 | 14.1 | > 360 |
| 1 | 1.8 | 225 | 243 | > 360 |
| 3 | 4.9 | 110 | 30.4 | > 360 |
| 5 | 3.5 | >320 | 317 | >360 |
| 2 | 0.5 | 109 | 47.1 | >360 |
| 4 | 4.1 | >320 | >491 | >360 |
| 6 | 6.1 | 191 | 62.6 | >360 |
