Table 1.

Comparison of avanafil pharmacokinetics to other available PDE5 inhibitors

Parameters	Sildenafil	Vardenafil	Tadalafil	Avanafil
Available doses, mg	25, 50, 100	5, 10, 20	5, 10, 20	20, 50, 100
Tmax, hours	1 (0.5–2.0)	0.7 (0.25–3.00)	2 (0.5–6.0)	0.593 (0.686–0.555)
t1/2, hours	3–5	4–5	17.5	1.19 (1.07–1.23)
Other possible receptor affinity	PDE6	PDE6	PDE11	PDE6