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The median time to extrahepatic metastases in patients with a PIVKA-II ≥ 300 mAU/mL. The cumulative metastasis-free rate was analyzed in a multivariate Cox regression model in patients with a PIVKA-II ≥ 300 in AJCC (1a; Hazard Ratio, HR = 2.7, 95% confidence interval [CI] = 1.535-4.812, adjusted P = 0.001) and BCLC stage BCLC (1b: HR = 3.7, 95% CI = 2.073-6.560, adjusted P < 0.001) adjusting for such covariates as platelet count, AFP ≥ 400, portal vein thrombosis, and stage.
