Figure 2. C225-NP regulates EGFR signaling pathway in tumor cells but not in normal cells.

Inhibitory effects of C225-NP on phosphorylated EGFR and the downstream signaling molecules in human lung cancer and normal cells. C225-NP treatment reduced the expression of phosphorylated (p) forms of EGFR, AKT, p38 MAPK, and P44/42 MAPK in EGFR-positive tumor cells but not in normal cells. There was no effect on EGFR-null H520 tumor cells.