Table 3. Haplotypes in the SIRT5, SIRT6 and UCP5 genes associated with carotid plaque (Bonferroni-corrected p≤0.05).
| Gene | SNPs | Haplotype | Freq. | Carotid plaque | exp(beta) (95% CI)* | Nominal p | Adjusted p∧ |
| SIRT5 | rs4712032, rs12175268, rs10498683, rs12216101 (LD block 3) | GCGG | 0.21 | Number | 1.16 (1.07–1.26) | 0.0004 | 0.009 |
| SIRT6 | rs107251, rs3760905 (LD block 13) | TT | 0.11 | Presence | 1.67 (1.20–2.32) | 0.002 | 0.05 |
| Number | 1.31 (1.18–1.45) | 5.0×10−7 | 1.1×10−5 | ||||
| UCP5 | rs6418932, rs12557276, rs2235800, rs16999665, rs5977248, rs4830187, rs4829716, rs4830188, rs5932754 (LD Block 16) | TTTCACATT | 0.07 | Presence | 0.45 (0.30–0.68) | 0.0002 | 0.005 |
| Number | 0.65 (0.64–0.78) | 6.4×10−6 | 1.5×10−4 |
*beta was estimated based on Logistic and Poisson regression, respectively, for presence and number of carotid plaque after adjusting for age, sex, smoking, hypertension, diabetes and waist-to-hip ratio as well as genomic control variables (PCAs).
∧
Bonferroni corrected p based on 23 tested haplotypes with a frequency>5% in SIRT5, SIR6 and UCP5 genes.