Table 4. SNPs showing interaction with sex and vascular risk factors for presence or number of carotid plaque with a nominal p≤0.01.
| Interaction analysis* | Stratified analysis exp(beta) (95% CI) for 1 minor allele change | |||||||
| Carotid plaque | Vascular risk factor (VRF) | SNP (gene) | Pvrf | Psnp | Pinteraction | exp(beta) for interaction (95% CI) | With VRF | Without VRF |
| Presence | Female | rs1685356 (UCP3) | 0.01 | 0.02 | 0.007 | 1.81 (1.17–2.79) | 1.42 (1.08–1.87) | 0.76 (0.54–1.08) |
| rs1726745 (UCP3) | 0.01 | 0.03 | 0.01 | 1.71 (1.13–2.59) | 1.38 (1.07–1.77) | 0.79 (0.56–1.10) | ||
| Number | Female | rs1430579 (UCP1) | 0.0004 | 0.0001 | 0.0003 | 1.30 (1.13–1.50) | 1.06 (0.97–1.16) | 0.80 (0.72–0.90) |
| rs1472268 (UCP1) | 0.0006 | 0.0002 | 0.0005 | 1.29 (1.12–1.49) | 1.05 (0.96–1.15) | 0.80 (0.72–0.90) | ||
| rs1472269 (UCP1) | 0.0005 | <.0001 | 0.0005 | 1.30 (1.12–1.51) | 1.02 (0.93–1.13) | 0.78 (0.69–0.88) | ||
| rs6829571 (UCP1) | 0.0005 | 0.0003 | 0.0006 | 1.29 (1.12–1.49) | 1.07 (0.97–1.17) | 0.82 (0.73–0.91) | ||
| Smoking | rs2841503 (SIRT5) | <.0001 | 0.0003 | 0.003 | 0.67 (0.52–0.87) | 0.98 (0.84–1.15) | 1.47 (1.20–1.82) | |
| rs6907892 (UCP4) | <.0001 | 0.05 | 0.005 | 0.80 (0.69–0.93) | 0.91 (0.82–0.99) | 1.12 (1.00–1.26) | ||
| Diabetes | rs10498683 (SIRT5) | <.0001 | 0.94 | 0.003 | 0.67 (0.51–0.87) | 0.71 (0.55–0.90) | 1.00 (0.89–1.12) | |
| rs6418932 (UCP5) | <.0001 | 0.28 | 0.006 | 0.77 (0.65–0.93) | 0.84 (0.71–1.00) | 1.04 (0.95–1.14) | ||
| rs12557276 (UCP5) | <.0001 | 0.002 | 0.008 | 0.76 (0.61–0.93) | 0.90 (0.74–1.10) | 1.14 (1.04–1.25) | ||
| rs2235800 (UCP5) | <.0001 | 0.25 | 0.004 | 0.76 (0.63–0.92) | 0.82 (0.69–0.98) | 1.05 (0.95–1.15) | ||
| rs4830187 (UCP5) | <.0001 | 0.002 | 0.004 | 0.74 (0.60–0.91) | 0.88 (0.72–1.07) | 1.14 (1.04–1.25) | ||
| rs4830188 (UCP5) | <.0001 | 0.34 | 0.006 | 0.76 (0.62–0.92) | 0.80 (0.66–0.97) | 1.04 (0.94–1.14) | ||
| rs5932754 (UCP5) | <.0001 | 0.37 | 0.009 | 0.77 (0.63–0.94) | 0.82 (0.68–0.99) | 1.03 (0.94–1.13) | ||
| Hypertension | rs10498683 (SIRT5) | <.0001 | 0.12 | 0.005 | 0.73 (0.58–0.91) | 0.84 (0.74–0.95) | 1.15 (0.96–1.38) | |
| rs9370232 (SIRT5) | <.0001 | 0.21 | 0.0004 | 0.69 (0.56–0.85) | 0.77 (0.69–0.87) | 1.12 (0.94–1.33) | ||
| rs536715 (SIRT3) | 0.003 | 0.0006 | 0.01 | 1.39 (1.08–1.78) | 0.95 (0.85–1.07) | 0.67 (0.54–0.84) | ||
| rs5977238 (UCP5) | <.0001 | 1 | 0.001 | 0.51 (0.34–0.77) | 0.51 (0.39–0.67) | 0.95 (0.69–1.30) | ||
*Pvrf, Psnp, Pinteraction and beta were, respectively, p-value for risk factor main effect, p-value for SNP main effect, p-value and regression coefficient for their interactive effect, based on Logistic (plaque presence) and Poisson (plaque count) regression models after adjusting for age, sex, smoking, hypertension, diabetes and waist-to-hip ratio as well as genomic control variables (PCAs) if applicable.