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. 2011 Nov 7;6(11):e27178. doi: 10.1371/journal.pone.0027178

Figure 1. Myc-CaP sensitivity to HDAC and mTORC1 inhibition.

Figure 1

(A) Myc-CaP cell lines were incubated with indicated concentrations of panobinostat or everolimus for 24 and 48 hours. Cell viability was determined by the uptake of PI and FACS analysis. (B) Myc-CaP cells were incubated with indicated concentrations of panobinostat or everolimus for 24 and 48 hours. Cell were fixed and stained with 10% MeOH in crystal violet. Final cell growth was determined by quantitating the absorbance at an optical density of 570 nm. (C–D) The clonogenic potential of Myc-CaP cell lines treated for 24 and 48 hours with panobinostat or everolimus alone or in combination and quantitated by image J analysis. Results shown represent the mean ± SE of 3 separate experiments. * p<0.05.